Fig 1: Lysosomal proteins LAMP-1 and LAMP-2 are upregulated in the CSF of AD patients. The CSF from ten NC and ten AD patients were analyzed using Western blot for lysosomal proteins. a Western blots of the lysosomal membrane proteins LAMP-1, LAMP-2, CD63, DRAM, LIMP-2, NPC1, SYT7 and V-ATPase. b Densitometric quantification of the Western blots in a. c Western blots of the luminal lysosomal proteases cathepsins B, D and L. d Densitometric quantification of the Western blots in c. The protein levels are normalized to the means of the respective NC samples. The bars represent the mean ±SD, *p < 0.05, ***p < 0.001