Description
Product Characteristics:
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular location: Nucleus
Synonyms: Cell proliferation inducing protein 54, Cell proliferation-inducing gene 54 protein, KIAA0648, PDS5A, PDS5A_HUMAN, PIG54, SCC-112, Sister chromatid cohesion protein 112, Sister chromatid cohesion protein PDS5 homolog A.
Target Information: The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]