Description
Product Characteristics:
Microtubules, the primary component of the cytoskeletal network, are highly dynamic structures composed of Alpha/Beta Tubulin heterodimers. Biosynthesis of functional microtubules involve the participation of several chaperones, termed Tubulin folding cofactors A (TBCA), B (TBCB), D (TBCD), E (TBCE) and C (TBCC), that act on folding intermediates downstream of the cytosolic chaperon, alternatively named TCP. TBCB (tubulin folding cofactor B), also known as CG22, CKAP1 or CKAPI, is a 244 amino acid cytoplasmic protein containing one CAP-Gly domain and in widely expressed. TBCB is involved in the regulation of tubulin heterodimer dissociation and may function as a negative regulator of axonal growth.
Subcellular location: Cytoplasm
Synonyms: CG22, CKAPI, Cytoskeleton associated protein 1, Cytoskeleton associated protein CKAPI, Cytoskeleton-associated protein 1, Cytoskeleton-associated protein CKAPI, TBCB, TBCB_HUMAN, Tubulin folding cofactor B, Tubulin specic chaperone B, Tubulin-folding cofactor B, Tubulin-specic chaperone B.
Target Information: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity)