Description
Product Characteristics: The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).
Target Information: Npl4-Ufd1 complex competes with p47 to bind p97 and inhibit Golgi membrane fusion, may play a role in ubiquitin mediated processes during mitosis