Description
Product Characteristics:
Neuron navigator 2 (NAV2), also known as RAINB1 (retinoic acid inducible in neuroblastoma 1), POMFIL2 (pore membrane and/or filament-interacting-like protein 2), HELAD1 (helicase APC down-regulated 1), unc53H2 or steerin-2, is a 2,488 amino acid nuclear protein that plays a role in the development of sensory organs. Existing as thirteen alternatively spliced isoforms, Neuron navigator 2 displays 3' to 5' helicase activity and exonuclease activity and participates in the catalysis of ATP to ADP. Neuron navigator 2 is highly expressed in the nervous system of developing embryos and colon carcinomas, as well as in liver, brain and kidney. Lower levels of expression are found in lung, thyroid, spinal cord, heart, placenta and mammary gland. Neuron navigator 2 belongs to the Nav/unc-53 family and contains one CH (calponin-homology) domain.
Subcellular location: Nucleus
Synonyms: HELAD1, Helicase, APC down regulated 1, KIAA1419, mCG 145366, mKIAA3015, NAV 2, Neuron navigator 2, POMFIL2, Pore membrane and/or filament interacting like protein 2, RAINB1, RAINB2, Retinoic acid inducible in neuroblastoma 1, Steerin 2, STEERIN2, Unc 53 homolog 2, Unc53H2, NAV2_HUMAN.
Target Information: This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]