Description
Product Characteristics:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Synonyms: ALIEN, Alien homolog, COP 9, COP9, COP9 constitutive photomorphogenic homolog subunit 2, COP9 signalosome complex subunit 2, COPS 2, Cops2, CSN2, CSN2_HUMAN, JAB1 containing signalosome subunit 2, JAB1-containing signalosome subunit 2, SGN 2, SGN2, Signalosome subunit 2, Thyroid Hormone Receptor Interactor15, Thyroid Hormone Receptor Interactor 15, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP 15, TRIP-15.
Target Information: transcriptional corepressor that may be involved in neural differentiation