Description
Product Characteristics:
Mad2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Subcellular location: Cytoplasm, Nucleus
Synonyms: HsMAD 2, MAD 2, MAD 2A, MAD2 like 1, MAD2 like protein 1, MAD2 mitotic arrest deficient like 1, Mitotic arrest deficient yeast homolog like 1, MD2L1_HUMAN.
Target Information: MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]