Description
Product Characteristics:
MGAT5 is a mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, 6-N-acetylglucosaminyltransferase, Alpha 1,36 mannosylglycoprotein, Alpha 1,6 mannosylglycoprotein 6 beta N acetylglucosaminyltransferase, Alpha mannoside beta 1,6 N acetylglucosaminyltransferase, Alpha mannoside beta 1,6 N acetylglucosaminyltransferase, Alpha- mannoside beta-1,6-N-acetylglucosaminyltransferase, Alpha-1, alpha-1,36-mannosylglycoprotein, Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase, Alpha-mannoside beta-1, alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase, Beta 1,6 N acetyl glucosaminyltransferase, beta-1,6-N-acetyl-glucosaminyltransferase, GGNT5, GlcNAc T V, GlcNAc-T V, GNT V, GNT VA, GNT-V, GNTV, GNTVA, Mannoside acetylglucosaminyltransferase 5, Mannosyl alpha 1,6 glycoprotein beta 1,6 N acetyl glucosaminyltransferase, mannosyl alpha-1,6--glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, Mgat5, MGT5A_HUMAN, N acetylglucosaminyl transferase V, N acetylglucosaminyltransferase V mannosyl alpha 1,6 glycoprotein, N-acetylglucosaminyl-transferase V, N-acetylglucosaminyltransferase V.
Target Information: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]