Description
Product Characteristics:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008].
Subcellular location: Extracellular
Synonyms: Matrix metalloproteinase-15, MMP 15,MMP15, Matrix metallopeptidase 15 membrane inserted, Matrix metalloproteinase 15, Membrane type 2 Matrix Metalloproteinase, Membrane type matrix metalloproteinase 2, MMP 15, MT MMP 2, MT2 MMP, MT2MMP, MTMMP 2, MTMMP2, SMCP 2, SMCP2, MMP15_HUMAN.
Target Information: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily\, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]