Description
Product Characteristics:
Neurotrophic protein, induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Subcellular location: Secreted
Synonyms: Pedf, Sdf3, EPC-1, Pedfl, AI195227, Pigment epithelium-derived factor, Caspin, Serpin F1, Stromal cell-derived factor 3, SDF-3, Serpinf1
Target Information: The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]