Description
Product Characteristics:
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
Subcellular location: Secreted
Synonyms: WIF-1, Wnt inhibitory factor 1, WIF1, UNQ191/PRO217
Target Information: The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]