Description
Product Characteristics: EIF4E recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.ProtocolsProvided below are standard protocols that you may find useful for product applications.Western BlotBlocking PeptidesDot BlotImmunohistochemistryImmunofluorescence ImmunoprecipitationFlow CytometyCell Culture
Synonyms: eIF-4F 25 kDa subunit, mRNA cap-binding protein, Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E,EIF4F, EIF4EL1, EIF4E
Target Information: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]