Fig 1: INSR suppressed TNBC cell migration and invasion.
Fig 2: INSR was significantly downregulated in TNBC and correlated with breast cancer progression.
Fig 3: Effects of GQWTF on 10-week high-fat diet induced mice. Body weight A was monitored once a week, and fasting blood-glucose (FBG) (B) every 2 weeks during 10-week trial. C Dynamic changes of blood glucose during oral glucose tolerance test (OGTT), and AUC is area under the blood glucose-time curves of OGTT. D The relative protein expression of PTPN1, PPARA, PPARG and phosphorylation of INSR in liver using western blot analysis. Data are shown as means ± SEM of ten (A, B) or six (C) or three (D) independent experiments. #p < 0.05, ##p < 0.01, compared with control group; *p < 0.05, **p < 0.01, compared with model group
Fig 4: Association of INSR expression with breast cancer patients' survival.
Fig 5: Effects of PAP on insulin signaling in MC3T3-E1 cells. (A) Western blot analysis of expression levels of insulin signaling pathway factors after treatment with the indicated concentrations of PAP for 7 days. (B) Western blotting and densitometric analysis of the phosphorylated and total InsR, IRS-1, Akt and ERK under 100 mg/l PAP treatment at 0, 15, 30, 60 and 120 min. Data are presented as mean ± SD. *P<0.05, ***P<0.001 vs. control group. PAP, pilose antler peptide; IRS, insulin receptor substrate; InsR, insulin receptor; t-, total; p-, phosphorylated; Ctrl, control.
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