BioVendor Laboratory Medicine, Inc.'s Neuroglobin Human, Mouse Monoclonal Antibody, Clone: 13C8 is a Mouse monoclonal antibody. It reacts with Human. This antibody has been shown to work in applications such as: Immunohistochemistry.
Description
Neuroglobin, 151 amino acid reside protein, mainly expressed in vertebrate brain and retina, is a recently identified member of the globin superfamily. Augmenting O(2) supply, neuroglobin promotes survival of neurons upon hypoxic injury, potentially limiting brain damage. Moreover, neuroglobin may be a novel oxidative stress-responsive sensor for signal transduction in the brain. Neuroglobin expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo, and neuronal survival after hypoxia is reduced by inhibiting neuroglobin expression with an antisense oligodeoxynucle-otide and enhanced by neuroglobin overexpression