Description
Product Characteristics:
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: EPG3, TANGO5, TMEM49, Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, HSPC292
Target Information: Required for organelle biogenesis, protein secretion, and development. Required for maintaining integrity of the endoplasmic reticulum. May play a role in autophagy