Description
Product Characteristics:
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: IL 1 RAPL 1, IL 1RAPL 1, IL-1-RAPL-1, IL-1RAPL-1, IL1R8, IL1RAPL 1, IL1RAPL, IL1RAPL-1, IL1RAPL1, Interleukin 1 receptor 8, Interleukin 1 receptor accessory protein like 1, Interleukin-1 receptor accessory protein-like 1, IRPL1_HUMAN, Mental retardation X linked 10, Mental retardation X linked 21, Mental retardation X linked 34, MRX 21, MRX 34, MRX10, MRX21, MRX34, Oligophrenin 4, Oligophrenin-4, Oligophrenin4, OPHN 4, OPHN4, Three immunoglobulin domain containing IL 1 receptor related 2, Three immunoglobulin domain-containing IL-1 receptor-related 2, TIGIRR 2, TIGIRR-2, TIGIRR2 antibodyX linked interleukin 1 receptor accessory protein like 1, X-linked interleukin-1 receptor accessory protein-like 1.
Target Information: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]