Description
Product Characteristics:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.
Subcellular location: Nucleus
Synonyms: 2810449N18Rik, AI043036, Mono ADP ribosyltransferase sirtuin 6, NAD-dependent deacetylase sirtuin-6, NAD-dependent protein deacetylase sirtuin-6, SIR2 like 6, SIR2 like protein 6, Sir2 related protein type 6, SIR2-like protein 6, SIR2L6, SIRT 6, SIRT6, SIR6_HUMAN, Sirtuin silent mating type information regulation 2 homolog 6 S. cerevisiae, Sirtuin 6, Sirtuin type 6, Sirtuin6.
Target Information: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]