LY 294002, PI3-kinase inhibitor ab120243 from Abcam

Product Specs
ItemLY 294002, PI3-kinase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120243
Quantity1 MG, 5 MG, 25 MG
Purity0.99
Typeinhibitor

Add to Compare List

Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Actomyosin Activity and Piezo1 Activity Synergistically Drive Urinary System Fibroblast ActivationAdvanced science (Weinheim, Baden-Wurttemberg, Germany)November 1, 2023Chen G, Gao X, Chen J, Peng L, Chen S, Tang C, Dai Y, Wei Q, Luo D.(Calyc, 0.1 nm, Abcam, ab141784), (‐)‐Blebbistatin (20 µm, MERCK, B0560), and LY29004(0.1 nm, Abcam, ab120243). Polyethylene Glycol (PEG)‐RGD Hydrogel Diacrylate‐terminated PEG (CAS NO.26570‐48‐9, Sigma) reacted

(2) The FoxO1-ATGL axis alters milk lipolysis homeostasis through PI3K/AKT signaling pathway in dairy goat mammary epithelial cellsJournal of Animal ScienceAugust 28, 2023Qiuya He, Liangjiahui GaoLiang, Fuhong Zhang, Weiwei Yao, Jiao Wu, Ning Song, Jun Luo, Yong Zhangwere plated into 60 mm dishes overnight before experiments. After treatment with insulin or LY294002 (ab120243, Abcam, Cambridge, USA) for 24 h, an inhibitor of PI3K, cells were lysed for 10 min on ice using RIPA

(3) The EGF/EGFR axis and its downstream signaling pathways regulate the motility and proliferation of cultured oral keratinocytesFEBS Open BioAugust 1, 2023Ryota Kobayashi, Emi Hoshikawa, Taisuke Saito, Orakarn Suebsamarn, Eriko Naito, Ayako Suzuki, Seiichiro Ishihara, Hisashi Haga, Kei Tomihara, Kenji IzumiCorp,529573,2 μm U0126,EMD Millipore Corp,662005,200 nm LLL12,BioVision,1792,200 nm LY294002,Abcam,ab120243,2 μm PF‐562271,Sigma‐Aldrich,PZ0387,3 μm EGFR (Phospho‐Try1092) Antibody,Signalway Antibody LLC,#11081,1 : 500

(4) IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic InflammationCellsMay 28, 2023Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kiminhibitors, PP2 and Akt inhibitor IV were purchased from Sigma-Aldrich, and U 73122 and LY 294002 (ab120243) were from Abcam (Cambridge, UK). The antibodies for anti-IRF3 and p-S396-IRF3 were obtained from Cell

(5) Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1Oncology ResearchFebruary 9, 2023FANBIAO KONG, KUN WU, LIMING PANG, YULIANG HUANG, LEI LI, JING XU, FEITONG LI, YAN QING, ZHONGYU WANG, XIURONG HUANG, et al.Cell Signaling Technology, Inc., USA. MTT assay kits (ab211091) and Akt pathway specific inhibitor LY 294002 (ab120243) were purchased from ABCAM (Shanghai, China). Reverse transcriptase-polymerase chain reaction (RT-PCR) kits

(6) Interfering with the expression of EEF1D gene enhances the sensitivity of ovarian cancer cells to cisplatinBMC CancerDecember 1, 2022Qia Xu, Yun Liu, Shenyi Wang, Jing Wang, Liwei Liu, Yin Xu, Yide QinC1022) were purchased from Beyotime Institute of Biotechnology. LY294002 (PI3K inhibitor; cat. no. ab120243) and MK-2206 (Akt inhibitor; cat. no. SF2712) were purchased from Abcam and Beyotime Institute of Biotechnology,

(7) Effects of cGMP/Akt/GSK-3β signaling pathway on atrial natriuretic peptide secretion in rabbits with rapid atrial pacingFrontiers in PhysiologyAugust 19, 2022Shuxia Cao, Chengyong Han, Chunhua Xuan, Xiangdan Li, Jing Wen, Dongyuan XuLY294002 group, the perfusate was collected as a control during the first 12 min. LY294002 (10 μmol/L, ab120243, Abcam) was added, and the perfusate was collected for 24 min. 8-Br-cGMP was added, and the perfusate

(8) Application of Bone Marrow Mesenchymal Stem Cells Effectively Eliminates Endotoxemia to Protect Rat from Acute Liver Failure Induced by ThioacetamideTissue engineering and regenerative medicineApril 1, 2022Jiang T, Xia G, Yang B, Zhang HW, Yin YS, Tang CW, Yang JH.for 10 days. To inhibit the PI3K/AKT/mTOR signaling pathway, the inhibitor LY294002 (20 μM; Cat. no. ab120243; Abcam) was added to the co-culture system on the first day. Immunofluorescence Cells were fixed with

(9) Nectin cell adhesion molecule 4 regulates angiogenesis through Src signaling and serves as a novel therapeutic target in angiosarcomaScientific reportsMarch 7, 2022Tanaka Y, Murata M, Tanegashima K, Oda Y, Ito T.microscope (Nikon, Tokyo, Japan). Reagents MMAE (ChemScene, Deerpark, NJ; CS-0837), LY294002 (Abcam; ab120243), dasatinib (Abcam; ab142050), MLR-1023 (Sigma-Aldrich, St. Louis, MO; SML0361), and cabozantinib (Selleck

(10) Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 PathwayOxidative medicine and cellular longevityJanuary 1, 2022Liu S, Jin Z, Xia R, Zheng Z, Zha Y, Wang Q, Wan X, Yang H, Cai J.Cell Signaling Technology (Danvers, MA, USA). Antibodies of Nrf2 (ab137550) and the PI3K/Akt inhibitor LY294002 (ab120243) were provided by Abcam (Cambridge, MA, USA). Antibodies of β-actin (20536-1-AP), HO-1 (27282-1-AP),

(11) Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) PathwayMedical Science MonitorMarch 26, 2021Yanhua Guan, Xu WangChina) was purchased from the Chengdu Yirui Biotechnology Co (http://www.yiruiplant.com/). LY294002 (ab120243, Abcam, UK) was used to inhibit phosphatidylinositol 3-kinase (PI3K). Forty healthy adult rats with

(12) The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 PathwayFrontiers in pharmacologyJanuary 1, 2021Chen L, Guo Y, Qu S, Li K, Yang T, Yang Y, Zheng Z, Liu H, Wang X, Deng S, et al.(SB203580) was purchased from Merck-Millipore (Billerica, MA, United States), and PI3K inhibitor (LY294002, ab120243) was purchased from Abcam. Statistical Analysis Data were expressed as mean ± standard error of the

(13) The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosisRedox BiologyJanuary 1, 2021Pengfei Liu, Gang Luo, Matthew Dodson, Cody J. Schmidlin, Yongyi Wei, Baris Kerimoglu, Aikseng Ooi, Eli Chapman, Joe GN. Garcia, Donna D. Zhangand anti-rabbit IgG (HRP) (1:3000, A-0545) antibodies were purchased from Sigma-Aldrich. LY294002 (ab120243) was purchased from Abcam. The rabbit normal IgG and antibodies against NRF2 (1:1000, sc-13032), sMAF

(14) Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt PathwayDrug Design, Development and TherapySeptember 21, 2020Hongfei Ke, Dexiang Liu, Tingting Li, Xili Chu, Danqing Xin, Min Han, Shuanglian Wang, Zhen Wangthe hydrogen concentration is >0.6 mmol and that the preparation is fresh with each use. LY294002 (ab120243, Abcam, Cambridge, MA), a PI3-kinase inhibitor, was diluted in phosphate-buffered saline (PBS). The

(15) WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m⁶A-dependent mannerCell death & diseaseAugust 19, 2020Chen S, Li Y, Zhi S, Ding Z, Wang W, Peng Y, Huang Y, Zheng R, Yu H, Wang J, et al.invasion, and wound-healing assay of osteosarcoma cell treated with 5 μM Akt inhibitor LY294002 (Abcam, ab120243) for 12 h.

(16) SNCG promotes the progression and metastasis of high-grade serous ovarian cancer via targeting the PI3K/AKT signaling pathwayJournal of experimental & clinical cancer research : CRMay 7, 2020Zhang J, Liu XH, Li C, Wu XX, Chen YL, Li WW, Li X, Gong F, Tang Q, Jiang D.Cy3-labeled goat anti-rabbit IgG (P0183), were purchased from Beyotime (Shanghai, China). LY294002 (ab120243) was obtained from Abcam (Cambridge, UK), Puromycin (sc-205,821) was purchased from Santa Cruz (CA,

(17) Neuroprotective Effect of Danhong Injection on Cerebral Ischemia-Reperfusion Injury in Rats by Activation of the PI3K-Akt PathwayFrontiers in PharmacologyMarch 11, 2020Chen Feng, Haofang Wan, Yangyang Zhang, Li Yu, Chongyu Shao, Yu He, Haitong Wan, Weifeng Jindiluted 1:500), AKT (ab179463, diluted 1:500) and the PI3K-Akt pathway specific inhibitor LY294002 (ab120243) were supplied by Abcam Biotech (Shanghai, China); DHI was purchased from Buchang Pharmaceutical Company

(18) Vinpocetine Protects Against Cerebral Ischemia-Reperfusion Injury by Targeting Astrocytic Connexin43 via the PI3K/AKT Signaling PathwayFrontiers in neuroscienceJanuary 1, 2020Zhao M, Hou S, Feng L, Shen P, Nan D, Zhang Y, Wang F, Ma D, Feng J.Hungary) during OGD/R injury; and (4) an OGD/R + Vinp + LY group, stimulated with LY294002 (20 μM) (ab120243, Abcam, Cambridge, MA, United States) and Vinp during OGD/R injury; (5) OGD/R + Vinp + BKM group, stimulated

(19) The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling NetworkOxidative medicine and cellular longevityJanuary 1, 2019Li X, Chen Y, Zhao J, Shi J, Wang M, Qiu S, Hu Y, Xu Y, Cui Y, Liu C, et al.anti-PI 3 kinase p85 alpha (phospho Y607) (Cat# ab182651), BAY117082 (Cat# ab141228), LY294002 (Cat# ab120243), U0126 (Cat# ab120241), Apoptotic DNA Ladder Detection Kit (Cat# ab66090), and Annexin V-FITC Apoptosis Staining/Detection Kit

(20) FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant ResponseFrontiers in pharmacologyJanuary 1, 2019Dong L, Li R, Li D, Wang B, Lu Y, Li P, Yu F, Jin Y, Ni X, Wu Y, et al.(ab34173), MPZ (ab31851), and Akt (ab179463), Histone H3 (ab176842) and the PI3K/Akt inhibitor LY294002 (ab120243), were purchased from Abcam. Antibodies against GAPDH (10494-1-AP), HO-1 (10701-1-AP), SOD2 (24217-1-AP),

Be the First to Write a Review!

Cell death & disease

LY 294002, PI3-kinase inhibitor from Abcam

Description

Abcam

Citations (25)

Reviews

LY 294002, PI3-kinase inhibitor from Abcam

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map