Fig 1: Expression of lipolysis-related proteins in five subtypes of breast cancer cells.MCF-7 (luminal-like), MDA-MB-453 (HER2), MDA-MB-435S (TNBC), MDA-MB-231 (TNBC), and MDA-MB-468 (TNBC) cells were lysed with RIPA buffer, and then cell lysates were subjected to SDS-PAGE and blotted with the indicated antibodies. Blots are representative of three independent experiments. TNBC, triple-negative breast cancer; HSL, hormone sensitive lipase; FABP4, fatty-acid binding protein 4; CPT-1A, carnitine palmitoyltransferase IA; ACOX1, Acyl-CoA oxidase 1; FASN, fatty acid synthase.
Fig 2: Expression of lipid metabolism related proteins according to the molecular subtypes of breast cancer.PLIN1, CPT-1A, and FASN expression are highest in HER2 tumors and lowest in TNBC tumors. Similarly, FABP4 and ACOX-1 expression are highest in HER2 tumors and lowest in luminal A tumors.
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