Fig 1: Examples of B-mode (A, C and E) and contrast enhanced (B, D and F) images from the three rabbits included in the study.Images A and B are from Rabbit 1, which was injected with strep-tritc-MBs with anti-ICAM1 2 hours after the onset of the inflammation. The images shown are recorded 22 hours after MB injection, and the area of inflammation is marked with white arrows. Images B and C are from Rabbit 2, which was injected with strep-tritc-MB with anti-ICAM1 24 hours after the inflammation was induced, and the images are recorded 48 hours after MB injection. The inflammation area and accumulation of MBs at its perimeter are marked by white arrows in the images. Some MBs are also detected further from the inflammation (right side of (D). In images E and F examples from Rabbit 3 are shown. The animal was given tritc-MB (MBs without streptavidin and antibodies) 24 hours after the inflammation was induced, and the images are recorded 48 hours after MB injection. The contrast enhanced image shows some MBs in the muscle tissue at the far-right end (red arrow), but no accumulation of MBs around the inflammation area (white arrow). B-mode images are recorded at 12 MHz and shown with a dynamic range of 69 dB and contrast enhanced images are recorded with imaging pulses of 9.5 MHz and a dynamic range of 36 dB.