Fig 2: The relationship among the expression levels of SOCS7/HuR/FOXM1 in the tumor tissues of HGSOC patient and their correlations with survival rate of HGSOC patients. a IHC staining analysis of SOCS7, HuR, and FOXM1 in the tumor tissues of HGSOC patients in cohort 2. Scale bar = 100 µm. b-d Spearman's correlation scatter plots for HuR-SOCS7 (b), HuR-FOXM1 (c) and FOXM1-SOCS7 (d) of HGSOC patients in cohort 2. e and f The overall survival of HGSOC patients with different protein levels of HuR (e) or FOXM1 (f) in cohort 2. g The overall survival of HGSOC patients with different protein levels of SOCS7, HuR, and FOXM1 in cohort 2. h Schematic model of the regulation of HGSOC tumor growth by SOCS7/HuR/FOXM1

Fig 3: HuR binds to the 3'UTR of FOXM1 and regulates its transcription. a and b Pearson's correlation scatter plots for FOXM1-SOCS7 (a) and FOXM1-HuR (b) of HGSOC patients (n = 30) in cohort 1. c Additional HuR RIPs followed by qRT-PCR on precipitates validated HuR binding of FOXM1 mRNA in CAOV3 cells transduced with indicated lentiviral vectors. d Relative luciferase activity of FOXM1 3'UTR in CAOV3 cells transduced with indicated lentiviral vectors. e Relative mRNA levels of FOXM1 in CAOV3 cells transduced with indicated lentiviral vectors and treated with 5 µg/ml actinomycin D. f-i HuR and FOXM1 expression in CAOV3 cells transduced with indicated lentiviral vectors. *P < 0.05, **P < 0.01 and ***P < 0.001, in related with shNC, Vector. ###P < 0.001, in related with SOCS7