Fig 2: Signatures of metastasis-associated myeloid subpopulations are associated with poor progression of human breast cancer. (A) UMAP plot of 52562 annotated cells in GSE114727 of human breast cancer. (B) The pie plots displaying cell proportions of cell types in blood, normal, and tumor groups. (C) UMAP clustering of human monocyte, macrophage, neutrophil, and DC subsets. (D) The dot plot comparing signatures of mouse Tppp3 + monocytes in human monocyte clusters. (E) UMAP plots labeled by cluster 0 of human monocytes. (F) The dot plot comparing signatures of mouse Isg15 + macrophages in human macrophage clusters. (G) UMAP plots labeled by cluster 5 of human macrophages. (H) The dot plot comparing signatures of mouse Ifit3 + neutrophils in human neutrophil clusters. (I) UMAP plots labeled by cluster 6 of human neutrophils. (J) The dot plot comparing signatures of mouse Il12b + DCs in human DC clusters. (K) UMAP plots labeled by cluster 3 of human DCs. (L) Survival plots showing associations clinical outcome and immune infiltrates combined with signature expression of the myeloid subpopulations in human BRCA (n=1100). High or low gene expression represents expression levels of marker genes of metastasis-associated myeloid populations.