Description
Product Characteristics: The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. FUNCTION: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. CATALYTIC ACTIVITY: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein.,Mammalian TRPM,Transient receptor potential cation channel subfamily M member 2, long transient receptor potential channel 2, LTrpC2, LTrpC-2, transient receptor potential channel 7, TrpC7, estrogen-responsive element-associated gene 1 protein, EREG1, KNP3, LTRPC2, TRPC7, KNP3
Target Information: The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]