Description
Product Characteristics: anti-mouse CD11a (Ly 15.2, LFA-1) monoclonal antibody identifies a cell sur- face glycoprotein consisting of two non-covalently associated chains with molecular weights of 180kDa ( chain) (1) present on most common lymphocytes and T and B cells.
Target Information: ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]