The CHOP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to DDIT3. This antibody recognizes Human, Mouse, and Rat antigen. The CHOP Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominant-negative manner (1). CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase (2). Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death (3). Studies also found that CHOP mediates the activation of GADD34 and Ero1-Lalpha expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2alpha thereby stimulating protein synthesis. Ero1-Lalpha promotes oxidative stress inside the endoplasmic reticulum (ER) (4). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER (4).
Similarity: The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300. Belongs to the bZIP family