The PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (Preservative free) DMF Filed from ACROBiosystems is a Human Monoclonal antibody. This antibody recognizes Mouse antigen. The PE-Labeled Monoclonal Anti-FMC63 Antibody, Mouse IgG1 (Y45) (Site-specific conjugation) (Preservative free) DMF Filed has been validated for the following applications: Flow Cytometry.
Description
FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas.
FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs.
So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta