Fig 1: Correlation between hub genes and infiltrating immune cells. (a–c) Association of CRTAM, CXCL13, and LRRC15 with 22 immune cells.
Fig 2: The mRNA expressions of hub genes were validated by qRT-PCR. *p < 0.05. (a–c) The mRNA expressions of CRTAM, CXCL13, and LRRC15 between control and RA rat synovial tissues (n = 8).
Fig 3: Validation of the hub genes. (a, b) Expression levels of CRTAM, CXCL13, and LRRC15 between normal and RA synovial tissues. Verification using two external datasets (GSE12021 and GSE55235). (c) The ROC curves analysis.
Fig 4: The protein expressions of hub genes were validated by western blot. ∗∗p < 0.001. (a–c) The protein expressions of CRTAM and LRRC15 between control and RA rat synovial tissues (n = 8).
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