Fig 1: Correlation between overall survival rates, SPRY members and clinicopathological factors. (a)–(c) Expression of SPRY1 (a), SPRY2 (b) and SPRY3 (c) displayed no prognostic significance. (d) Low expression of SPRY4 was significantly correlated with low overall survival rates in PHCC patients. (e)–(h) Advanced patient age (e), positive lymph node metastasis (f), positive distant metastasis (g) and advanced TNM stage (h) were all associated with poor prognosis. Results were analyzed using the Kaplan–Meier method, and the statistical significance between groups was assessed using the log-rank test.
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