Fig 1: Involvement of CRKL and the VEGF signaling pathway. (A) Western blot confirmed decreased expressions of CRKL and pCRKL in 22q11.2DS-SCZ (Student’s t-test p = 0.0079 for total CRKL and p = 0.0018 for pCRKL). (B) RT-qPCR confirmed alterations in CRKL (Student’s t-test p = 0.003), VEGFR1/FLT1 (p = 0.038), VEGFR2/KDR (p = 0.03), EPAS1/HIF-2a (p = 0.047), and PHLDA1 (p = 0.007) in 22q11.2DS-SCZ (sample size = 6, technical repeats = 5). (C). A working model of how alterations in CRKL-VEGF receptor interactions lead to deficits in the junction barriers. Ncase = 3, Ncontrol = 3, and error bar = standard deviation for all analyses.