Fig 1: High stromal NNMT expression predicts an unfavorable survival in chemotherapy CRC. A, Associations between stromal NNMT expression and survival of stage II CRC patients with or without chemotherapy. B, Associations between stromal NNMT expression and outcomes in the stage III CRC patients with or without chemotherapy. Kaplan-Meier survival curves of NNMT-high (green line) and NNMT-low (blue line) patients with stage II and stage III CRC who did or did not receive postoperative adjuvant chemotherapy are shown. P-values and HRs are from Kaplan-Meier analysis with log-rank test
Fig 2: The association between stromal NNMT expression and survival of patients with earlier stage CRC (I and II stage). A, High IHC-score of NNMT is associated with poor survivals of patients with early stage CRC. B, High NNMT expression predicts poor DSS of patients with early stage colon cancer. C, High NNMT expression is associated with poor survivals of patients with early stage rectum cancer
Fig 3: High IHC-score of NNMT predicts poor survivals of patients with CRC. (A-C) CRC patients, colon cancer and rectum cancer patients were dichotomised into the subgroups with NNMT-high or NNMT-low protein expression according to NNMT IHC-score (cut-off value = 106). Disease-specific survival and disease-free survival are presented. Log-rank P values and hazard ratios (HRs) from Kaplan-Meier analysis with log-rank test are shown
Fig 4: NNMT protein is elevated in colorectal cancer stroma and epithelium. A, Representative examples of immunostaining of NNMT in CRC and adjacent normal tissues, adenoma tissues, paracarcinoma tissues and metastasis tissues. Bar, 50 µm. B, IHC-score scatterplot (R software) of stomal NNMT and epithelial NNMT. NNMT is mainly expressed in the cytoplasm of colorectal stromal cells. (color density representation of a scatterplot) C, Expression pattern of NNMT protein in formalin-fixed paraffin-embedded specimens of CRC and adjacent normal tissues, adenoma tissues, paracarcinoma tissues and metastasis tissues. The differences of NNMT protein expression between colon cancer vs rectum cancer. *P < .05; **P < .01; ***P < .001
Supplier Page from MilliporeSigma for Anti-NNMT antibody produced in rabbit