Fig 1: The RANKL/OPG ratio is decreased in the necrotic bones of IV BP-induced advanced-stage MRONJ patients. (a) High-magnification images (400×) of the immunohistochemistry analysis of RANKL (left) and OPG (right) expression in the specimens of the two patient groups as indicated. Scale bars = 50 µm. Statistical analysis of the number of RANKL-positive (b), and OPG-positive (c) cells, and the RANKL/OPG ratio (d), via the Mann–Whitney U test (n = 20 per group). ° marks statistical outliers. For detailed data, see Table 2. * p < 0.001.