Fig 1: Rodents metabolomics analysis and BCAA metabolism.Panel a: sPLS-DA explains 63.7% of the variance of the variables of interest. Panel b: Heat map of metabolites before and 1 months after SG. sPLS-DA, Partial least-squares discriminant analysis. Panels c-d: BCAT2 and BCKDH protein expression increased in the heart of SG rats when compared to sham-operated animals. Glyceraldehyde 3-phosphate dehydrogenase (GPDH). BCAT2, Branched Chain Amino Acid Transaminase 2; BCKDH, branched-chain α-ketoacid dehydrogenase complex. *P = 0.016 (Holm-Bonferroni method). Data are mean ± SEM (n = 5 rat per group).