Fig 1: LncRNA RP11-19E11.1 is an E2F target gene.a RNA expression fold-change of E2F family transcription factors after RP11-19E11.1 knock-down from RNA-seq data. Each point represents the fold-change in each cell line, and for each gene mean value ± SD is represented. b Western blot for E2F1 and E2F3 after RP11-19E11.1 after 18 and 24 h using LNA3. c Motif enrichment analysis in the RP11-19E11.1 promoter for E2F transcription factor. d Chromatin immunoprecipitation (ChIP) using E2F1 antibody in HCC38. Two biological replicates are shown (two-tailed unpaired t test). e RNA levels of CCNE2 and RP11-19E11.1 in HCC38 and SUM149PT after exogenous overexpression of E2F1 (two-tailed paired t test). Each point represents a single measurement. Data are presented as mean ± SEM. *P < 0.05; **p < 0.01; ***p < 0.001.