Fig 1: Traumatic impact-induced changes in gene expression. RT-PCR analysis of the expression of genes related to cartilage anabolism (SOX9, COL2A1 and ACAN), cartilage catabolism (MMP13, and ADAM-TS4&5) and cell stress (iNOS and PTGS2) in engineered cartilage constructs subjected to 30% strain versus samples exposed to 10 ng/ml IL-1ß at 1, 3 and 7 days of culture. n = 20/group. #p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05