Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb 2992T from Cell Signaling Technology

Product Specs
ItemPhospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb
CompanyCell Signaling Technology
Price Pricing Info Supplier Page View Company Product Page
Catalog Number2992T
ClonalityMonoclonal
ReactivityHu, Ms
Research AreaRTK
Molecular Weight190
NCBI Gene AliasesCD140A, PDGFR-2, PDGFR2
NCBI Full Gene Nameplatelet derived growth factor receptor alpha
ApplicationsWB, IP
HostRabbit
IsotypeIgG
TargetPDGFR-a (Tyr754) phosphate
Quantity20 µl

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchangeDevelopmental cellJuly 11, 2022Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT.RRID:AB_2162351 Rabbit monoclonal anti-Phospho-PDGF Receptor α (Tyr754) (23B2),Cell Signaling Technology,Cat# 2992; RRID:AB_390728 Goat polyclonal anti-PDGF R beta,R&D Systems,Cat# AF1042; RRID:AB_2162633 Rat monoclonal

(2) Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondriaeLifeApril 6, 2022Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT.Cell Signaling Technology, Cat# 3164), rabbit anti-phospho-PDGFRA (Tyr754) (1:100, Cell Signaling Technology, Cat# 2992), mouse anti-S6 ribosomal protein (1:100, Cell Signaling Technology, Cat# 2317), and rabbit anti-phospho-S6 ribosomal protein (Ser235/236

(3) Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligandScientific ReportsMarch 3, 2022Kerrie A. Morrison, Laura Wood, Karen J. Edler, James Doutch, Gareth J. Price, Francoise Koumanov, Paul Whitley(19H7) (1:500); Anti Phospho-Akt (Ser473) (193H12) (#4058) (1:1000); Anti phospho-PDGFR-α (Tyr754) (#2992) (1:1000); Anti PDGFR-α (#3174) (1:1000) were supplied by Cell Signalling Technology®. Pan 14-3-3 (K-19)

(4) PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cellsPloS oneJanuary 1, 2022Kim JO, Baek SE, Jeon EY, Choi JM, Jang EJ, Kim CD.purchased from Proteintech (Chicago, IL, USA). PDGFR-α (3164S), PDGFR-β (3169S) and phospho-specific (2992S, 3166S) antibodies were obtained from Cell Signaling Technology (Beverly, MA, USA). β-Actin (sc-47778)

(5) In Silico Screening and Validation of PDGFRA Inhibitors Enhancing Radioiodine Sensitivity in Thyroid CancerFrontiers in pharmacologyJanuary 1, 2022Yu X, Zhu X, Zhang L, Qin JJ, Feng C, Li Q.for the western blot were as follows: monoclonal antibodies against phospho-PDGFRA (Tyr754, Cat. No. 2992), Na+/K+ ATPase (Cat. No. 3010), and GAPDH (Cat. No. 5174) were purchased from Cell Signaling Technology

(6) Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling PathwaysInternational journal of molecular sciencesNovember 14, 2021Mannsåker TA, Hoang T, Aasen SN, Bjørnstad OV, Parajuli H, Sundstrøm T, Thorsen FA.the following antibodies: phospho-PDGFR-α (Cell Signaling Technology, Inc., Danvers, MA, USA, cat. #2992); phospho-MERTK (Abcam, Cambridge, UK, cat. #14921); phospho-IGF1 (Abcam, cat. #39398); phospho-DDR1

(7) Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drugCell ReportsNovember 2, 2021Junfeng Bi et al.,Cell Signaling,Cat#3174; RRID:AB_2162345 "Rabbit Anti-pPDGFRA-Tyr754, Clone 23B2 (WB 1:1000)",Cell Signaling,Cat#2992; RRID:AB_390728 "Rabbit Anti-FGFR1, Clone D8E4 (WB 1:1000)",Cell Signaling,Cat#9740; RRID:AB_11178519 "Mouse

(8) Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelinationBrain and behaviorOctober 1, 2021Cardona HJ, Somasundaram A, Crabtree DM, Gadd SL, Becher OJ.3164S), 1:1000; myelin basic protein (MBP, CST, 78896), 1:1500; phospho‐Tyr762 PDGFRA (pPDGFRA, CST, 2992), 1:1000; ERK1/2 (CST, 9107), 1:1000; phospho‐Thr202/Tyr204 ERK1/2 (pERK1/2, CST, 9101), 1:1000; Akt

(9) Comparative Evaluation of qnrA, qnrB, and qnrS Genes in Enterobacteriaceae Ciprofloxacin-Resistant Cases, in Swine Units and a Hospital from Western RomaniaAntibiotics (Basel)October 14, 2020Alexandru O. Doma, Roxana Popescu, Mihai MituleÈ›u, Delia Muntean, JÃ¡nos DÃ©gi, Marius V. Boldea, Isidora Radulov, Eugenia Dumitrescu, Florin Muselin, Nikola PuvaÄa, et al.Methylase RmtB-Producing Escherichia coli Isolates from Pigs. Antimicrob. Agents Chemother. 2008, 52, 2992–2993. [CrossRef] Poirel, L.; Nguyen, T.V.; Weintraub, A.; Leviandier, C.; Nordmann, P. Plasmid-mediated

(10) GZD824 as a FLT3, FGFR1 and PDGFRÎ± Inhibitor Against Leukemia In Vitro and In VivoTranslational OncologyApril 1, 2020Yuting Wang, Lenghe Zhang, Xia Tang, Jinfeng Luo, Zhengchao Tu, Kaili Jiang, Xiaomei Ren, Fang Xu, Shingpan Chan, Yuhua Li, et al.Cyclin E1 (20808S), Cyclin D2 (2924), CDK2 (2546S), CDK4 (12790S), PDGFRα (3174), phosphor-PDGFRα (2992 T), Stat3 (9132S), phosphor-Stat3 (9145S), GAPDH- (2118) and anti-rabbit (7074S) or anti-mouse IgG horseradish

(11) Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell ModelScientific reportsJanuary 29, 2020Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin-Roger J, Schefer F, Weder B, Hausmann M, Scharl M, Rogler G, et al.After blocking with 3% bovine serum albumin (BSA), cells were incubated with LC3 antibody (Cat No. 2992, Cell Signalling Technology) at 1:200 dilution overnight at 4 °C. Cells were then incubated with an

(12) WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cellsProceedings of the National Academy of SciencesNovember 26, 2019Tatiana N. Moiseeva, Chenao Qian, Norie Sugitani, Hatice U. Osmanbeyoglu, Christopher J. BakkenistMK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8, 2992–3000 (2009). Moiseeva et al. BRIEF REPORT Materials and Methods Antibodies. Antibodies included MCM4

(13) Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid TumorsCell reportsAugust 27, 2019Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, et al.AB_2756824 SMARCB1/SNF5,Bethyl,Cat#A301-087; RRID: AB_2779664 p-PDGFRα (Tyr754) (23B2),Cell Signaling,Cat#2992 ; RRID: AB_390728 p-PDGFRα (Tyr762),Cell Signaling,Cat#12022; RRID: AB_2636868 PDGFRα,Cell Signaling,Cat#3164;

(14) An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunityProceedings of the National Academy of Sciences of the United States of AmericaAugust 27, 2019Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham MH, Hay RT, Hale BG.Mount Sinai, New York, NY), PKR (abcam; ab32052), MDA5 (Cell Signaling; 5321), MAVS (Cell Signaling; 2992), STING (Cell Signaling; 13647), FLAG M2 (Sigma; F1804), and ubiquitin FK2 (Millipore; 04-263). SUMO

(15) The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in GlioblastomaFrontiers in oncologyJanuary 1, 2019Cheng F, Zhang P, Xiao Q, Li Y, Dong M, Wang H, Kuang D, He Y, Duan Q, Mao F, et al.(Cell Signaling Technology, Cat# 3174S), rabbit anti-phospho-PDGFRα (Cell Signaling Technology, Cat# 2992), rabbit anti-MET (Cell Signaling Technology, Cat# 8198), rabbit anti-phospho-MET (Cell Signaling Technology,

(16) Relative Suffix TreesThe Computer JournalMay 1, 2018Andrea Farruggia, Travis Gagie, Gonzalo Navarro, Simon J Puglisi, Jouni SirÃ©n(M),Approx (M),Inv (M),Time (min),Memory (GB),Time (min),Memory (GB),Time (min),Memory (GB) Yes,3096,3036,2992,2980,1.42,4.41,175,84.0,629,141 No,3036,3036,2991,2980,1.33,4.38,173,82.6,593,142 Sequence lengths

(17) Midostaurin, a Natural Product-Derived Kinase Inhibitor Recently Approved for the Treatment of Hematological MalignanciesPublished as part of the Biochemistry series "Biochemistry to Bedside"BiochemistryFebruary 6, 2018Paul W. Manley, Ellen Weisberg, Martin Sattler, James D. Griffinpermission from Cell Signaling Inc. Reprinted with permission from Zarrinkar et al. Blood 2009;114:2984–2992.

(18) The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinomaOncogeneNovember 23, 2017Govaere O, Petz M, Wouters J, Vandewynckel YP, Scott EJ, Topal B, Nevens F, Verslype C, Anstee QM, Van Vlierberghe H, et al.(Cell Signaling Technologies, Danvers, MA, USA, 5241), phospho-PDGFRα (Cell Signaling, Technology, 2992), K19 (Thermo Fisher Scientific, MS-1902-P1), Ln-111 (Abcam, ab7463), La/SSB (Santa Cruz Biotechnology,

(19) Biochanin-A induces apoptosis and suppresses migration in FaDu human pharynx squamous carcinoma cellsOncology ReportsNovember 1, 2017In-A Cho, Sang-Joun You, Kyeong-Rok Kang, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You, Gyeong-Je Lee, Yo-Seob Seo, Do Kyung Kim, Chun Sung Kim, et al.total p-38, phospho-Akt, total Akt, matrix metalloproteinase (MMP)-2 ONCOLOGY REPORTS 38: 2985-2992, 2017 2987 Figure 1. Biochanin-A induces cell death through the increase of cytotoxicity in FaDu cells.

(20) Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic strokeActa neuropathologicaOctober 1, 2017Su EJ, Cao C, Fredriksson L, Nilsson I, Stefanitsch C, Stevenson TK, Zhao J, Ragsdale M, Sun YY, Yepes M, et al.Ltd., Osaka, Japan), rabbit anti-phospho-tyrosine (pY) 754 or -1018 specific PDGFRα (1:200, pY754 #2992 and pY1018 #4547; Cell Signaling, Danvers, MA, USA). Goat anti-CD31 or goat anti-podocalyxin antibodies

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Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb from Cell Signaling Technology

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