Since its inception almost 75 years ago, gel electrophoresis has facilitated insights into protein structure and function, including groundbreaking discoveries like DNA’s double helix and the first genome maps of entire organisms. Over time, new gel materials have boosted resolution and flexibility, and advanced imaging and detection systems have yielded step changes in sensitivity and accuracy. Demand for capillary electrophoresis systems is expected to soar in coming years, driven by biopharma interest in monoclonal antibodies and other protein targets of therapeutic interest.

Agilent, a leader in laboratory systems, has introduced the new ProteoAnalyzer automated, parallel capillary electrophoresis system to meet this demand for precise, reliable, and efficient protein quality control across a wide range of protein types. The system is optimized for workflows across pharma, biotech, food analysis, and academia and thoughtfully designed to minimize downtime.

By automating separation and data processing and simplifying sample preparation steps, the ProteoAnalyzer streamlines protein analysis, reduces hands on-time, and improves consistency. Samples can be loaded and the next run programmed while a separation is ongoing. Accurate results eliminate the need for time-consuming and costly reanalysis.

Between runs, the capillaries are automatically cleaned, rejuvenated, and filled with fresh separation gel. This ensures superior data quality, even with challenging samples like crude lysates. Digital data processing accelerates results and minimizes subjectivity and human error. Data is also easy to archive, recover, or import into LIMS systems for further analysis.

The Agilent ProteoAnalyzer is also versatile. With twelve discrete capillaries, the system can, in a single run, analyze a wide range of sample sizes, from 10 to 240 kDa. Diverse samples, including purified proteins, antibodies, crude lysates, and membrane proteins, can be analyzed in the same run. The ProteoAnalyzer is appropriate for protein sizing and quantification analysis under reduced and non-reduced conditions.

Proteins are central to understanding cellular function, disease mechanisms, genetic research and biomarker discovery. Armed with reliable results from the Agilent ProteoAnalyzer, scientists across a diverse range of disciplines will be able to make informed decisions faster and with more confidence.

For Research Use Only. Not for use in diagnostic procedures. PR7001-2077