Fig 1: Cortical and hippocampal BDNF, CD68, and MAP-2 levels. (A) In males, BDNF levels in the cortex were higher levels in mice irradiated with 50 cGy than sham-irradiated mice. *p = 0.026. (B) In males, there was a trend toward higher CD68 levels in mice irradiated with 50 cGy than sham-irradiated mice. #p = 0.082, Dunnett’s. (C) There was a positive correlation between BDNF and CD68 levels in the cortex. r = 0.703, p < 0.0001, Pearson correlation (sham-irradiated and irradiated mice combined in the analysis). (D) There was also a positive correlation between cortical BDNF and CD68 levels in only sham-irradiated mice. r = 0.907, p < 0.0001, Pearson correlation. (E) There was also a positive relationship between hippocampal BDNF and CD68 levels. r = 0.7985, p < 0.0001, Pearson correlation (sham-irradiated and irradiated mice combined in the analysis). (F) There was a positive correlation between hippocampal BDNF and CD68 in only sham-irradiated mice. r = 0.837, p < 0.0001, Pearson correlation. (G) There was a negative correlation between cortical MAP-2 and CD68 levels. r = -0.6314, p < 0.0001, Pearson correlation (sham-irradiated and irradiated mice combined in the analysis). (H) In contrast to the cortex, there was a positive relationship between MAP-2 and CD68 in the hippocampus. r = 0.7529, p < 0.0001, Pearson correlation (sham-irradiated and irradiated mice combined in the analysis).