Fig 1: Synovial MMP-3 level from CIA rats. Rats (n = 10/group) were orally treated with UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks post model induction. Data are Mean ± log10SD.
Fig 2: Comparison between the different studied groups according to IL–1 beta (pg/ml) (a), MDA (nmol/ml) (b), NO (µm) (c), Aggrecan level (pg/mL) (d) and MMP3 (ng/mL) (e) in joint homogenate. The data are reported as the mean ± SD (n = 6). *: p < .05, **: p < .01, ***: p < .001, ****: p < .0001 and ns: non-significant.
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