Fig 1: Plasma biochemistry. (A) DBH. xp < 0.05 vs. SD-SAL; td = 1.9, rd = 2.1 vs. FSL-SAL; vd = 1.8, ud = 2.0 vs. FSL-FLX. (B) CORT. xp < 0.05 vs. SD-SAL; #p < 0.05 vs. FSL-SAL; yd = 0.8 vs. SD-SAL; zd = 0.8 vs. FSL-SAL; vd = 0.8 vs. FSL-FLX. (C) IL-6. No significant effects between cohorts were observed. (D) TNF-a. yd = 1.1 vs. SD-SAL; wd = 0.8 vs. FSL-SAL; zd = 0.9 vs. FSL-FLX. Data were analysed using two-way ANOVA followed by Bonferroni post hoc test and Cohen's d analysis. Data are presented as mean ± SEM. Detailed p–values in the text. CORT, corticosterone; DBH, dopamine-beta-hydroxylase; FSL, Flinders' Sensitive Line; FLX, fluoxetine; IL-6, interleukin 6; SAL, saline; SD, Sprague-Dawley; SIR, social isolation rearing; TNF-a, tumour necrosis factor-alpha.
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