Fig 1: Effect of chronic administration HBK-15 and fluoxetine on corticosterone-treated mice behavior (a–c) and BDNF (d) and NGF (e) levels in the hippocampus. Corticosterone (20 mg/kg) was injected subcutaneously (s.c.) for 3 weeks at random times during the light phase. Additionally, 30 min before, corticosterone administration mice were intraperitoneally (i.p.) injected with HBK-15 (0.625 or 1.25 mg/kg), fluoxetine (10 mg/kg), or 0.9% NaCl (saline). Control groups received saline (i.p.) and 30 min later saline containing 0.1% dimethyl sulfoxide (DMSO) and 0.1% Tween-80 (vehicle, s.c.). The doses are indicated in brackets. Statistical analysis: one-way ANOVA (Newman–Keuls post hoc); *p < 0.05, **p < 0.01 vs control (non-corticosterone-treated ) (saline, gray); # p < 0.05, ## p < 0.01, ### p < 0.001 vs corticosterone-treated control (saline, red); n = 8 mice per group (animal studies), n = 6 mice per group (biochemical studies) (color figure online) BDNF - brain-derived neurotrophic factor, NGF - nerve growth factor