Fig 1: A gene specific effect accompanies 5-aza-CR demethylating action.Exposure to the modifier didn’t affect the transcription of several histones (HIST1H2AC, HIST2H2AC and HIST1H4E), or resulted in downregulation of COL6A3 and CCNG1. Furthermore, a sharp upregulation of HAT1, and a decrease of HDAC1 was detected after exposure to 5-aza-CR. Different superscripts denote significant differences between groups (P < 0.05).