Fig 2: (A) Decreased serum levels of sirtuin 3 (SIRT3) in systemic sclerosis (SSc) patients with features of interstitial lung disease (ILD) on high-resolution computed tomography scan of the chest. Data are presented as box plots. Each box denotes the 25th to 75th percentiles. Lines outside the boxes are the 10th and 90th percentiles. Lines inside the boxes denote the median, circles denote the outliers, and asterisks denote the extreme values. (B) Correlation of serum SIRT3 levels with pulmonary function measured as percentage forced vital capacity (%FVC) in patients with SSc. (C) Correlation of serum SIRT3 levels with percentage diffusing capacity of the lungs for carbon monoxide (%DLCO) in patients with SSc. Data are displayed as scatterplot, where each dot represents a patient. Correlation coefficient (?) and p values are indicated.

Fig 3: Serum levels of sirtuin 3 (SIRT3) are decreased, and correlate with the extent of skin fibrosis in systemic sclerosis (SSc) patients. (A) Serum SIRT3 levels in healthy controls, SSc patients and limited cutaneous SSc (lcSSc), and diffuse cutaneous SSc (dcSSc) subsets. Data are presented as box plots. Each box denotes the 25th to 75th percentiles. Lines outside the boxes are the 10th and 90th percentiles. Lines inside the boxes denote the median, circles denote the outliers, and asterisks denote the extreme values. (B) Correlation of SIRT3 levels with modified Rodnan skin thickness score (mRSS) in SSc patients. Data are displayed as scatterplot, where each dot represents a patient. Correlation coefficient (?) and p values are indicated. N.S., not significant.