Fig 1: Regulation of nerve fiber growth in endometriotic lesions of mice with induced endometriosis. (a) The protein levels of NGF (left) and IGF-1 (right) in the peritoneal fluid were analyzed by sandwich ELISA. The data were normalized with the average levels in mice treated with vehicle (n = 15 for each group). (b) Immunofluorescence staining was performed to detect the presence of nerve fibers (PGP9.5+) in endometriotic lesions from different groups (left). The fluorescence intensity was averaged by using data from 10 independent tissue sections (right). Statistical differences between vehicle and drug-treated groups were compared by t-test. The p values were presented as *: p value < 0.05, **: p value < 0.01, and ***: p value < 0.001.