Fig 1: The effects of DMF (60 mg/kg; 30 mg/kg twice a day; p.o.), BCP (2.5, 5 mg/kg/day; p.o.), and the combination of a CB2 antagonist AM630 (1 mg/kg; i.p.) with BCP (5 mg/kg/day; p.o.) on intracellular levels of Arg-1 and iNOS and their products, urea, and NO of microglia isolated from EAE mice; (A) iNOS; (B) Arg-1; (C) ratio of iNOS/Arg-1 (M1/M2); (D) NO; (E) Urea; (F) ratio of NO/Urea (M1/M2). Data were presented as Mean ± SEM, n = six animals per group for each experiment protocol. Two-way ANOVA and Tukey’s multiple comparisons test were performed. (*) indicates the comparison between varying doses of BCP or DMF groups to the vehicle group, *: p < 0.05, **: p < 0.01, and ***: p < 0.001; (+) makes a comparison between the vehicle and sham groups, +++: p < 0.001; # in comparison to DMF group in each graph, #: p < 0.05, ##: p < 0.01, and ###: p < 0.001.