Fig 1: The level of inflammatory- and scar-related protein in the DRG. (A) Experimental paradigm. (B) PGE2, (C) TNF-α, (D) NF-κβ, (E) iNOS, (F) COX-2, and (G) 5-LOX in DRG tissues. (H) The expression of collagen I and fibronectin in DRG tissues at 0, 3, 7, and 14 days following injury, as evidenced by western blot analysis. (I) Protein data quantification from (H). Data are provided as mean ± SD, with n = 4 per treatment. *p < 0.05, **p < 0.01, and ***p < 0.001 were deemed significant.
Fig 2: Pro-inflammatory markers and inflammatory enzymes levels in the sciatic nerve and brainstem on day 14 after the surgery. (A) PGE2, (B) TNF-α, (C) NF-κβ, (D) iNOS, (E) COX-2, and (F) 5-LOX in sciatic nerve and brainstem tissues. Data (n = 5) are expressed as means ± SEM. Data were analyzed with One-way ANOVA and Tukey test. *, # and @ denote p < 0.05 from sham, CCI, and pregabalin, respectively.
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