Fig 1: Box and whisker plots illustrating the spread of data between serum ligands and the grade of total skin toxicity in patients with metastatic colorectal cancer who received anti-epidermal growth factor (EGF) receptor antibody treatment. The width of each box plot is drawn proportional to the square root of the number of observations in the groups. Skin toxicity was divided into low grade (G0–G1) and high grade (G2–G3). AREG, amphiregulin; EREG, epiregulin; HGF, hepatocyte growth factor; IGF-1, insulin growth factor-1; NRG, neuregulin; TGF-α, transforming growth factor-α.
Fig 2: Graphic representations of serum levels of ligands by ELISA Serum levels of EGF, TGF-alpha, EREG, AREG, NRG, HGF and IGF-1 are shown in Table 1The serum levels of some samples of EGF (n = 8), TGF-alpha (n = 35) and AREG (n = 26) were less than the lower limits of the detectable range of ELISA.
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