Fig 1: Effect of heparin on anti-coagulation and fibrinolysis parameters in an LPS-induced sepsis rat model. (A) AT and (C) PAI-1 were determined using an ELISA at 0.5, 2 and 6 h after LPS injection, respectively. Effect of UFH or NAH on (B) AT and (D) PAI-1 in plasma at 2 and 6 h after LPS injection. Data are presented as mean ± standard deviation. There were 6 animals in each group at 0.5, 2 and 6 h, respectively. *P<0.05 vs. the control group; #P<0.05 vs. the LPS group. The AT data were analyzed using a Kruskal-Wallis test along with Bonferroni correction. The PAI-1 data were analyzed using a one-way analysis of variance followed by a Student-Newman-Keuls test for multiple group comparisons. LPS, lipopolysaccharide; AT, antithrombin; PAI-1, plasminogen activator inhibitor-1; UFH, unfractionated heparin; NAH, N-acetylheparin.