Fig 1: Establishment of a model of heart failure with sarcopenia C57BL6/J mice were separated into control, sham, HF, HF + sarcopenia group. (A) Echocardiography: LVEF (%) and LVFS (%). (B) Serum BNP (pg/mL), LDH (U/L), CK level (U/mL). (C) Exercise capacity detection: forelimb grip strength test, hanging grid test, exhaustive running test, and ratio of gastrocnemius weight to tibial length. (D) Hematoxylin-eosin (HE) staining and cross section area (CSA) of muscle fibers (μm2). N = 5–12. *P < 0.05 vs. control, #P < 0.05 vs. HF. Bar = 40 μm.
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