Fig 1: Effect of PEF on the levels of plasma CORT and CRH. The levels of plasma CORT were shown in a, and the levels of plasma CRH were shown in b. Values were expressed as mean±SEM (##P<0.01 vs control group, *P<0.05, **P<0.01 vs SPS group, n=10–12)
Fig 2: Schematic of the possible mechanism underlying the anxiolytic effect of the Jie-Yu-He-Huan capsule. The Chinese medicine formula Jie-Yu-He-Huan can ameliorate anxiety-like behaviours in rats exposed to chronic restraint stress by normalising the overactivated HPA axis function, ultimately regulating the 5-HT system, and finally targeting the cAMP-PKA-CREB-BDNF signalling pathway. HPA: hypothalamic–pituitary–adrenal; JYHH: Jie-Yu-He-Huan capsule; CRS: chronic restraint stress; CRH: corticotropin-releasing hormone; ACTH: adrenocorticotropic hormone; GR: glucocorticoid receptor; CORT: corticosterone; PFC: prefrontal cortex; 5-HT: 5-hydroxytryptamine; 5-HT1AR: 5-HT1A receptor; cAMP: cyclic adenosine monophosphate; PKA: protein kinase A; CREB: cAMP response element-binding protein; BDNF: brain-derived neurotrophic factor.
Fig 3: Effect of simulated altitude at 5500 m on HPT axis and HPA axis hormones. Serum levels of CRH (a), ACTH (b), CORT (c), TRH (d), tT4 (e). Data were expressed as mean ± SEM. n = 6/group. **p < 0.01, ***p < 0.001, ****p < 0.0001 compared to control group using two-tailed unpaired t-tests. CRH corticotropin-releasing hormone, ACTH adrenocorticotropic hormone, CORT corticosterone, TRH thyrotropin-releasing hormone, tT4 thyroxine.
Supplier Page from CUSABIO Technology LLC for Rat corticotropin releasing hormone,CRH ELISA Kit