Fig 1: TDP-43 is elevated in ADEVs extracted from subjects with an autopsy-confirmed diagnosis of LATE. Plasma concentrations of TDP-43 were detected in NDEVs, ADEVs, and MDEVs (A-F) and in EV depleted plasma (G,H) as measured by our in-house ELISA and Cusabio kit. NDEV concentrations TDP-43 was not significantly different between LATE-NC (+) and LATE-NC (–) subjects (A,D). ADE concentrations of TDP-43 were significantly increased in LATE-NC (+) as compared to LATE-NC (–) subjects (B,E). MDEV concentrations of TDP-43 were significantly increased in LATE - NC (+), as measured by our in-house ELISA (C), while MDE concentrations of TDP-43 were significantly decreased in LATE-NC (+), as measured by the Cusabio kit (F). EV depleted plasma concentrations of TDP-43 were not significantly different between LATE-NC (+) (n = 22) and LATE-NC (–) subjects (n = 42).
Fig 2: Correlations between TDP-43 accumulation in NDEVs, ADEVs, and MDEVs against cognition-based variables including MMSE score and Braak NFT staging; sex; and APOEe4 carrier status as measured by our Cusabio kit. No correlation was observed with TDP-43 accumulation in NDEVs, ADEs, and MDEs with a lower MMSE score (A–C) or Braak NFT stage (D–F). NDEV, ADE, and MDE concentrations of TDP-43 were not significantly different in females versus males (G–I) or between APOEe4 carriers and non-carriers (J–L). (n = 22, LATE-NC (+); n = 42, LATE-NC (–) subjects).
Fig 3: Correlations between TDP-43 accumulation in NDEVs, ADVEs, and MDVEs against cognition-based variables including MMSE score and Braak NFT staging; sex; and APOEe4 carrier status as measured by our in-house ELISA. No correlation was observed with TDP-43 accumulation in NDEVs, ADEVs, and MDEVs with a lower MMSE score (A–C) or Braak NFT stage (D–F). NDEV, ADEV, and MDEV concentrations of TDP-43 were not significantly different between females versus males (G–I) or between APOEe4 carriers and non-carriers (J–L). (n = 22, LATE-NC (+); n = 42, LATE-NC (–) subjects).
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